The Alkaloids most used are those of tea, coffee, kola-nut, cocoa, coca, tobacco and opium. Although the two last are generally smoked, they must be classed amongst the food adjuncts. It is of little consequence whether their active principles enter the body by the mouth and saliva or the lungs; their action on the blood and nervous system is the same. The Extractives, as they are called, comprise a number of bodies of varying nature. They especially exist in flesh and flesh extracts. Amongst these are the purins. They will be treated at greater length hereafter. Alcohol is to some extent a true food, but its stimulant and other action quite overshadows any food value it may possess. There are other bodies such as the resins and bitters. The active principle of Indian hemp is a resin. There is a great difference of opinion as to the extent to which stimulants may advantageously be used. It is remarkable that amongst nearly all nations, either alcohol in some form or one of the stronger alkaloids is in common use. From this fact it is sometimes argued that stimulants must supply a physiological need. The same method of reasoning will apply with greater force to the use of condiments. Such conclusions appear to us to be scarcely warranted. If the extensive or even universal practice of a thing proves its necessity, then has there been justification, either now or in the past, for war, lying, avarice and other vices. It is strange that drugs differing so greatly in their immediate and obvious effects as, for example, alcohol and opium, or coffee and tobacco should be used. Should it he said that only some of the much used stimulants are useful, there is an end to the argument based on their universal use. There is no doubt that the use of stimulants in more than very small quantities is distinctly injurious, and it is difficult to see what physiological advantage there can be in their habitual use, to what is vaguely called a moderate extent. Sometimes they are taken for a supposed medical necessity, and where taste attracts, little evidence satisfies. Those in the habit of taking them, if honest, must confess that it is chiefly on account of the apparent enjoyment. The ill-nourished and the depressed in body and mind crave most for stimulants. A food creates energy in the body, including the nervous system, and this is the only legitimate form of stimulation. A mere stimulant does not create but draws on the reserve forces. What was latent energy--to become in the natural course gradually available--under stimulation is rapidly set free; there is consequently, subsequent depletion of energy. There may occasionally be times when a particular organ needs a temporary stimulus to increased action, notwithstanding it may suffer an after depression; but such cases are so rare that they may be left out of our present argument, and stimulants should only be used, like other powerful drugs, under medical advice.