Almost any type of central nervous system disease may be simulated as the result of focal sporulation so that we have aphasic, epileptiform, hemiplegic, bulbar and other clinical types. Some authors have recorded cases of multiple neuritis of malarial origin. Catto has recently examined the blood of a number of cases of multiple neuritis in Jamaica and has obtained negative malarial findings in every case. Neuralgic manifestations are features of latent malaria. Some loss of memory may be apparent after severe malaria. _The Special Senses._—Plugging of the retinal arteries may lead to blindness which may be either transient or lasting. The discs are grayish red instead of white as is the case with quinine amblyopia. The ringing in the ears is connected with the quinine treatment. _The Genito-urinary System._—In the cold stage there is apt to be frequent urination with increased secretion. Later on, there is a scanty febrile urine. Albuminuria is rather common in aestivo-autumnal attacks and true nephritis occurs in about 2% of cases. Plehn attaches great importance to the examination of the urine for urobilin as showing malarial infection when parasites cannot be found. The pigment particles in urinary sediment (Uriola) do not give reliable information. Bile in the urine is an important sign of bilious remittent fever. Orchitis has been reported as a malarial complication. _The Liver and Spleen._—There is very little of importance to note in connection with the liver except tenderness and jaundice in bilious remittent fever. The spleen, however, is the organ in which centers the infection and its tenderness and enlargement are of special diagnostic value in malaria. Even in comatose conditions pressure on the spleen may bring about indications of pain. The liability to rupture of the friable spleen of aestivo-autumnal infections is a real danger and the patient should not expose himself to injury. _The Blood Examination._—This is of prime value in the recognition of malaria, and one should examine both fresh blood preparations and stained films as well. More information is gotten from the stained films but we should also avail ourselves of the different characteristics of the 3 malarial species, which can be noted in a preparation made by taking up a small drop of exuding blood on a cover-glass and allowing it to drop on a slide and run out without any pressure on the cover-glass. The crescents, when found, show a malignant tertian infection but there may also be present one of the benign parasites. A stained film should be used to identify malignant tertian young ring forms.