I can do no more than indicate in the briefest possible way some of the more important views ascribed to Hippocrates. We cannot touch upon the disputes between the Coan and Cnidian schools.(25) You must bear in mind that the Greeks at this time had no human anatomy. Dissections were impossible; their physiology was of the crudest character, strongly dominated by the philosophies. Empedocles regarded the four elements, fire, air, earth and water, as "the roots of all things," and this became the corner stone in the humoral pathology of Hippocrates. As in the Macrocosm--the world at large there were four elements, fire, air, earth, and water, so in the Microcosm--the world of man's body--there were four humors (elements), viz.,blood, phlegm, yellow bile (or choler) and black bile (or melancholy), and they corresponded to the four qualities of matter, heat, cold, dryness and moisture. For more than two thousand years these views prevailed. In his "Regiment of Life" (1546) Thomas Phaer says:". . . which humours are called ye sones of the Elements because they be complexioned like the foure Elements, for like as the Ayre is hot and moyst: so is the blooud, hote and moyste. And as Fyer is hote and dry: so is Cholere hote and dry. And as water is colde and moyst: so is fleume colde and moyste. And as the Earth is colde and dry: so Melancholy is colde and dry."(26) (25) The student who wishes a fuller account is referred to the histories of (a) Neuburger, Vol. 1, Oxford, 1910; (b) Withington, London, 1894. (26) Thomas Phaer: Regiment of Life, London, 1546. As the famous Regimen Sanitatis of Salernum, the popular family hand-book of the Middle Ages, says: Foure Humours raigne within our bodies wholly, And these compared to foure elements.(27) (27) The Englishman's Doctor, or the Schoole of Salerne, Sir John Harington's translation, London, 1608, p. 2. Edited by Francis R. Packard, New York, 1920, p. 132. Harington's book originally appeared dated: London 1607. (Hoe copy in the Henry E. Huntington Library.)