After the defeat of the Tuscaroras and Yemassees about this time in the Carolinas, similar opportunities for expansion existed there. The cattle drovers sometimes took their herds from range to range; sometimes they were gathered permanently near the pens, finding the range sufficient throughout the year. They were driven to Charleston, or later sometimes even to Philadelphia and Baltimore markets. By the middle of the century, disease worked havoc with them in South Carolina[89:1] and destroyed seven-eighths of those in North Carolina; Virginia made regulations governing the driving of cattle through her frontier counties to avoid the disease, just as in our own time the northern cattlemen attempted to protect their herds against the Texas fever. Thus cattle raisers from the coast followed the fur-traders toward the uplands, and already pioneer farmers were straggling into the same region, soon to be outnumbered by the tide of settlement that flowed into the region from Pennsylvania. The descriptions of the uplands by contemporaneous writers are in glowing terms. Makemie, in his "Plain and Friendly Persuasion" (1705), declared "The best, richest, and most healthy part of your Country is yet to be inhabited, above the falls of every River, to the Mountains." Jones, in his "Present State of Virginia" (1724), comments on the convenience of tidewater transportation, etc., but declares that section "not nearly so healthy as the uplands and Barrens which serve for Ranges for Stock," although he speaks less enthusiastically of the savannas and marshes which lay in the midst of the forest areas. In fact, the Piedmont was by no means the unbroken forest that might have been imagined, for in addition to natural meadows, the Indians had burned over large tracts.[89:2] It was a rare combination of woodland and pasture, with clear running streams and mild climate.[89:3]