Of the names mentioned above there are several that belong to men who were in various ways connected with the early history of medicine. Pythagoras, for example, is said to have been one of the first among the Greek philosophers to exert a strong and double impression upon the medical teaching of that period. He was born in the Island of Samos, near the coast of Asia Minor, about the year 575 B. C. After spending several years in Egypt for purposes of study, and probably visiting Babylon, at that time a great centre of learning and of artistic cultivation, he established at Crotona, in the south of Italy, a school[22] where natural philosophy, mathematics, acoustics, etc., were taught. He also devoted some attention to anatomy, to embryology, to physiology and to therapeutics. According to his views of what constituted hygienic living a man should accustom himself to a diet of the simplest character, without meat. Pythagoras was a believer in the Chaldean doctrine that the uneven numbers possess a more important significance than the even, and that the number seven in particular has a special relationship to the phenomena of certain diseases; the crisis frequently falling on the seventh, fourteenth, or twenty-first day. Galen, it is said, expressed surprise that a man as sensible and learned as Pythagoras should have paid any attention to such trifles. Not a few of the disciples of Pythagoras were physicians, and when the brotherhood (if such it may be called) broke up, as it did in the fifth century B. C., these men traveled about from one Grecian city to another; from which fact they were given the name of “periodeuts” or ambulant physicians. Crotona was also celebrated as the birthplace of Milo, the athlete. Democedes, who was a contemporary of Pythagoras, but not one of his disciples, was a native of Crotona. Dion Cassius, the author of a Roman history, ranks him and Hippocrates as the two most eminent physicians of antiquity. Daremberg, who derived his facts from the works of Herodotus, gives the following account of the adventures of Democedes:--