In 1864, scorning the arts of diplomacy which he did not apparently understand, Lopez sent down an order for the two big states to leave the matter of Uruguayan politics to his impartial adjustment. At both Rio de Janeiro and Buenos Aires a roar of laughter went up from the press at this notion of an obscure chieftain of a band of Indians in the tropical backwoods daring to poise the equilibrium of much more than half a continent on his insolent hand. But the merriment soon subsided, as Brazilians and Argentinos came to realize what their peril might be from a huge army of skilled and valiant soldiers, a veritable horde of fighting fanatics, drawn up in a compact little land, centrally located and affording in other respects every kind of strategic advantage. When Brazil invaded Uruguay and restored the Colorados to power, Lopez demanded permission from Argentina to cross its frontier, for the purpose of assailing his enemy from another quarter. When the permission was denied, Lopez declared war on Argentina also. It was in every respect a daring step, but Lopez knew that Argentina was not so well prepared as his own state for a war of endurance. Uruguay then entered into an alliance in 1865 with its two big "protectors." In accordance with its terms, the allies agreed not to conclude peace until Lopez had been overthrown, heavy indemnities had been exacted of Paraguay, its fortifications demolished, its army disbanded, and the country forced to accept any boundaries that the victors might see fit to impose. Into the details of the campaigns in the frightful conflict that ensued it is not necessary to enter. Although, in 1866, the allies had assembled an army of some fifty thousand men, Lopez continued taking the offensive until, as the number and determination of his adversaries increased, he was compelled to retreat into his own country. Here he and his Indian legions levied terrific toll upon the lives of their enemies who pressed onward, up or down the rivers and through tropical swamps and forests. Inch by inch he contested their entry upon Paraguayan soil. When the able-bodied men gave out, old men, boys, women, and girls fought on with stubborn fury, and died before they would surrender. The wounded escaped if they could, or, cursing their captors, tore off their bandages and bled to death. Disease wrought awful havoc in all the armies engaged; yet the struggle continued until flesh and blood could endure no more. Flying before his pursuers into the wilds of the north and frantically dragging along with him masses of fugitive men, women, and children, whom he remorselessly shot, or starved to death, or left to perish of exhaustion, Lopez turned finally at bay, and, on March 1, 1870, was felled by the lance of a cavalryman. He had sworn to die for his country and he did, though his country might perish with him.