And now I must bring these lectures to a close. In doing so I feel that I have not only to thank you, Sir, and the Fellows of the Medical Society and our visitors for the favour with which I have been received and the patience with which you have listened to me, but at the same time to apologise for the many defects, both in matter and in form, of what I have presented to you. It is a fortunate circumstance for me that, whilst the subject was so large and so difficult, the mode of treatment of it commonly associated with the Lettsomian Lectures and your kind forbearance have enabled me to conceal my shortcomings by free selection of less severely scientific topics, and the employment of an easy style. At the same time, may I claim a little of your favourable consideration for the aspect in which I have regarded the disorders and diseases of the heart and arteries in middle and advanced life? I should be satisfied with the results of my efforts on this occasion, whatever may be thought of their form, if I have succeeded in convincing you of the practical advantage of regarding these complaints from the side of their causes as well as of their pathological anatomy. HARRISON AND SONS, Printers in Ordinary to His Majesty, St. Martin's Lane. INDEX. Acute disease and cardio-vascular degeneration; 39 Alcohol and cardiac disease; 9, 18 Alcoholism, Heart in, Course of; 20 Alcoholism, Heart in, Pathology of; 3, 19, 20 Alcoholism, Heart in, Prognosis of; 36 Alcoholism, Heart in, Symptoms and signs of; 13 Alcoholism, Heart in, Treatment of; 42 Angina pectoris; 17, 21, 24 Angina pectoris, false; 35 Angina pectoris, Prognosis of; 40 Angina pectoris, Significance of; 35 Arteries, The, at 20 to 45; 3 Arteries, The, at 45 to 65; 3, 4 Arteries, The, at 65 to 75; 4 Arteries, Degeneration of, and Gout; 7 Arteries, Diseases of, after 40, causes of; 6 Arteries, Soundness of, after 40; 5 Atheroma and Gout; 7 Atheroma, Treatment of; 44 Beneke, Professor, on the normal Arteries after 40; 3 Beneke, Professor, on the normal Heart after 40; 3 Bright's disease and cardio-vascular disease; 11, 29 Bruit de galop; 35 Causes of cardio-vascular disease; 9 Coffee and cardiac disorders; 9 Compensation, Maintenance of; 44 Cycling and cardiac strain; 6 Diabetes and cardio-vascular disease; 10 Diagnosis, Differential, of cardio-vascular disease; 3 Emphysema and cardio-vascular disease; 11 Exercise, Abuse of, and cardio-vascular disease; 8, 26 Exercise, after 40, Uses of; 45 Failure of Heart, Treatment of; 48 Failure of Heart, with Digitalis; 49 Failure of Heart, with Drainage; 49 Failure of Heart, with Purgatives; 49 Faintness, significance of; 35 Fatty degeneration, Diagnosis of; 47 Fatty degeneration, Treatment of; 47 Fevers, Acute specific, and cardio-vascular disease; 11 Glycosuria and Heart Disease; 22