I have heard her say this herself, in his presence, shortly before her death. For the last few weeks she took scarcely any nourishment, and could with difficulty swallow her medicine. The principal cause of this difficulty lay in the extreme nausea which followed any attempt to swallow, but it was greatly increased by the painful and constricted state of the throat, which was extremely rough and raw, and rendered swallowing very painful. As the disease progressed the vomited matter became strongly coloured with bile, and was of a strong yellow colour. The opression on the heart also increased, until at length respiration was almost impeded. The heart and pulses also gradually lost power, and latterly the lower portion of the body was almost paralysed, the limbs being stiff, and the whole frame, from the waist downward, very heavy and cold. The patient also suffered from severe cold perspirations, as well as from heat and irritation of the upper portion of the body, and from entire inability to sleep. A very remarkable feature in the case was, that notwithstanding this general sleeplessness, each fresh attack of the malady was preceded by a sound slumber of some hours duration, from which she appeared to be aroused by the return of the more active symptoms of the disorder. I tried all the usual remedies indicated by such symptoms, but without any permanent effect, and I was a good deal perplexed by the anomalous appearance of the case, and especially by its intermittent character, the symptoms recurring, as I have said, with increased severity, at regular intervals of about a fortnight. I mentioned my difficulty to Mr. Anderton, and asked if he would wish further advice. At his urgent request I consented, though with some hesitation, to meet Baron R**, who holds, as I was given to understand, a regular diploma from several of the foreign Universities, but whose practice has been of a somewhat irregular character. I first consulted with him on the 12th July.[2] [Dr. Dodsworth here details at some length how he became convinced of the Baron's great skill and knowledge of chemistry, and was finally persuaded to meet him in consultation.]