I was in attendance on the late Mrs. Anderton during the illness which terminated fatally on the 12th October, 1856. I was first sent for by Mr. Anderton, on the night of the 5th of April[1] in that year. I found her suffering apparently from a slight attack of English cholera, but was unable to ascertain any cause to which it might be attributed. There was nothing to lead to any suspicion of poisoning, indeed this seemed to be rendered almost impossible by the length of time that had elapsed since the last time of taking food and that at which the attack commenced. This was at least three or four hours; whereas, had the symptoms arisen from the action of any poisonous substance, they would have shown themselves much earlier. This is only my impression from after consideration. No idea of poison occurred to me at the time, nor should I now entertain any were I called in to a similar case. I prescribed the usual remedies for the complaint under which I supposed Mrs. Anderton to be suffering. They appeared to have their effect, though not so rapidly as I should have expected. The symptoms appeared rather to wear themselves out. I visited her several times, as the debility which ensued seemed greater than, under ordinary circumstances, should have followed on such an attack. About a fortnight later she had a fresh seizure, of a very similar kind. This time, however, the symptoms were aggravated, and accompanied by others of a more alarming character. Of these the most conspicuous were nausea, vomiting, violent perspiration, and increasing tendency to diarrhoea. The patient also complained of great sinking of the heart, and of a terrible lowness of spirits, almost amounting to a conviction that death was at hand. In the course of another fortnight or three weeks there was a fresh recurrence of the symptoms. The tongue, which in the former attacks had been clammy and dry, was now covered thickly with dirty mucus, and there was a greatly increased flow of saliva. The condition of the tongue became greatly aggravated as the disease progressed, the mouth and throat becoming ultimately very sore, with great constriction of the latter. The abdomen was distended, and very tender to the touch, the liver also being very full and tender. Pulse low and rapid, decreasing in fulness as the disease progressed, and reaching finally to 130 or 140; and the depression of spirits and sinking at the heart considerably increased. The patient appeared to be daily losing strength, and at each attack, which seemed to return periodically at intervals of about a fortnight, the same symptoms appeared more severely than before. Mr. Anderton seemed to be in the deepest distress. From the time when the symptoms first became serious, he hardly ever left her side, administering both food and medicine with his own hand. So far as I am aware, Mrs. Anderton took nothing of any kind from any other person throughout the greater portion of her illness.