Dr Beaumont began his experiments in May 1825, and continued them for four or five months, St Martin being then in high health. In the autumn, St Martin returned to Canada, married, had a family, worked hard, engaged as a voyageur with the Hudson’s Bay Fur Company, remained there four years, and was then engaged at a great expense by Dr Beaumont to come and reside near him on the Mississippi, for the purpose of enabling him to complete his investigations. He came accordingly in August 1829, and remained till March 1831. He then went a second time to Canada, but returned to Dr Beaumont in November 1832, when the experiments were once more resumed, and continued till March 1833, at which time he finally left Dr Beaumont. He now enjoys perfect health, but the orifice made by the wound remains in the same state as in 1824. Dr Beaumont describes the aperture in St Martin’s stomach as being situated about three inches to the left of the cardia, near the left or superior termination of the great curvature. When the stomach was nearly empty, he was able to examine its cavity to the depth of five or six inches by artificial distention. When it was entirely empty, the stomach was always contracted on itself, and the valve generally forced through the orifice, together with a portion of the mucous membrane equal in bulk to a hen’s egg. After sleeping for a few hours on the left side, the protruded portion became so much larger, as to spread “over the neighbouring integuments five or six inches in circumference, fairly exhibiting the natural _rugæ_, villous membrane, and mucous coat, lining the gastric cavity. This appearance is almost invariably exhibited in the morning before rising from bed.” Such was the very favourable subject on whom Dr Beaumont’s observations and experiments were made, and such were the numerous opportunities which he enjoyed for repeating them, and verifying their accuracy. Having given this outline, we now return to the consideration of the gastric juice, on the origin and qualities of which it removes any uncertainty which previously existed.