But indeed there are proofs of this antagonism still nearer to hand. How frequently have our physicians observed an eruption[169] resembling _roseola_ or _urticaria_ in character, at the—very often sudden—appearance of which the gonorrhoeal symptoms have much decreased in severity or disappeared altogether! These skin affections have been ascribed to the balsam of Copaiva or the Cubebs pepper administered in these cases, which are supposed to have stimulated the intestinal mucous membrane and so sympathetically excited the skin. This may very possibly sometimes be the case; but it could not but occur much more frequently, if the remedial agents mentioned are to bear the sole and entire blame. No doubt in some patients a particular idiosyncrasy may have given rise to sympathetic action stimulative of the intestinal canal, but in the majority the reaction of the mucous membrane of the genitals on the cutaneous glands has undoubtedly been a chief contributory factor under epidemic influences, while the drugs exhibited have played only a subordinate part in producing the result. There are cases where the gonorrhœa has been treated simply and solely by mere antiphlogistic methods, and yet such an eruption has been observed. But it is not in gonorrhœa only that these phænomena appear; they have been noted as well in chancre, being then ascribed to the sublimate of mercury and looked upon as affording a criterion that the drug had exercised its full effect on the original complaint. In most cases this was without doubt a mistake, for Biett, Rayer and other authorities have noted the most widely divergent forms of skin-disease to appear concurrently with the existence of chancre, and in consequence have come to regard them as primitive symptoms. In fact cases have actually been observed, where these were the sole primary symptoms of contagion after indulgence in unclean coition. At the same time it is only fair to say that this has been doubted in many quarters, observers trying to explain the fact of the absence of other symptoms by saying the ulcers, which are frequently very minute, may have been overlooked. At least experience has sufficiently taught us this much, that the so-called secondary symptoms, and therefore the skin-affections as well, appear the more readily in proportion as the ulcers of the genitals are smaller and more superficial; and we ourselves believe that never without local reaction on the genital organs from coition do so-called secondary appearances arise,—only it is not invariably ulcers that are to looked for.