In Texas, when the horse-flies are numerous, they attack animals without mercy, and where a contusion is found in the skin they deposit eggs, which speedily produce worms in great numbers. I have tried the effect of spirits of turpentine and several other remedies, but nothing seemed to have the desired effect but calomel blown into the wound, which destroyed the worms and soon effected a cure. In the vicinity of the South Pass, upon the Humboldt River, and in some sections upon other routes to California, alkaline water is found, which is very poisonous to animals that drink it, and generates a disease known in California as "_alkali_." This disease first makes its appearance by swellings upon the abdomen and between the fore legs, and is attended with a cough, which ultimately destroys the lungs and kills the animal. If taken at an early stage, this disease is curable, and the following treatment is generally considered as the most efficacious. The animal is first raked, after which a large dose of grease is poured down its throat; acids are said to have the same effect, and give immediate relief. When neither of these remedies can be procured, many of the emigrants have been in the habit of mixing starch or flour in a bucket of water, and allowing the animal to drink it. It is supposed that this forms a coating over the mucous membrane, and thus defeats the action of the poison. Animals should never be allowed to graze in the vicinity of alkaline water, as the deposits upon the grass after floods are equally deleterious with the water itself. In seasons when the water is low in the Humboldt River, there is much less danger of the alkali, as the running water in the river then comes from pure mountain springs, and is confined to the channel; whereas, during high water, when the banks are overflowed, the salts are dissolved, making the water more impure. For _colic_, a good remedy is a mixture of two table-spoonfuls of brandy and two tea-spoonfuls of laudanum dissolved in a bottle of water and poured down the animal's throat. Another remedy, which has been recommended to me by an experienced officer as producing speedy relief, is a table-spoonful of chloride of lime dissolved in a bottle of water, and administered as in the other case. RATTLESNAKE BITES. Upon the southern routes to California rattlesnakes are often met with, but it is seldom that any person is bitten by them; yet this is a possible contingency, and it can never be amiss to have an antidote at hand. Hartshorn applied externally to the wound, and drunk in small quantities diluted with water whenever the patient becomes faint or exhausted from the effects of the poison, is one of the most common remedies. In the absence of all medicines, a string or ligature should at once be bound firmly above the puncture, then scarify deeply with a knife, suck out the poison, and spit out the saliva.