Notwithstanding the medicine and the severity of the weather, I desired he would get on his cloaths, and go into the air as much as he could possibly bear; and in the evening ordered him to be carried in a chaise to the house provided for him in case he had been ill from inoculation. I examined the incisions carefully, but there were not the least signs of the infection having succeeded, either by discolouration, hardness, or any alteration on the skin, nor could he recollect that they had itched, or given him the least uneasiness. In the evening he came to the house as ordered, but was so very feeble and full of complaints, that it was with great difficulty he was got to his room. Upon inquiry I found he had vomited up the salts soon after taking them, and had only one costive stool; he had complied with my orders about getting into the air several times in the day, though with great difficulty. His complaints of thirst, pain in the head and back, were at this time very great. I directed him to sit with his feet in warm water for a short time, and, on going into bed, to take a few spoonfuls of a laxative mixture, which was to be repeated till he had stools. 9th. He had been delirious in the night, but rested a little towards the morning; the number of pustules was now considerably increased. This day he had three stools from his purging mixture, by which he was relieved, and bore sitting up better. 10th. He passed the night easy, but without sleep. He was very full in the face, but had a smaller number on the body and limbs. No complaint, deserving notice, happened during the progress to maturation. He sat up a part of every day to the eighth from the eruption, when, being blind, and very sore, he kept in bed: they turned on the eleventh, and he recovered perfectly. It was remarkable in this case, that the inoculated parts never shewed the least signs of infection; nor did a greater number of pustules appear near them than might have been expected if nothing had been done; nor is there to be seen the least mark where the inoculation was performed, though in all other inoculated patients who have had the disease, even in the slightest manner, there constantly remains a scar. It appeared, on inquiry, that this man had been, for a considerable time before, in a constant intercourse with families in the small-pox; and there seems not to be the least doubt but his was the natural disease. CASE XXVI.