3. The theory does not account for any changes which are not immediately beneficial. [Footnote: In the "Origin of Species" (Ed. 1872) Mr. Darwin makes an admission which is virtually a giving-up of his whole theory. He says, "In many other cases modifications are probably the direct result of the laws of variation or of growth, independently of any good having been thus gained; but even such structures have often, as we may feel assured, been subsequently taken advantage of," pp. 165, 166. Here, then, we have a preparation for future circumstances, which surely implies design.] If any rudimentary advance is made in the organism, if, for instance, the rudiments of a new bone, or joint, or organ of sense are developed, the nascent organ must, according to the hypothesis of minute changes, be useless in the first instance. Hence it would confer no advantage in the struggle of life; there would be no tendency towards its preservation and growth. This becomes a very important consideration, when certain important differences in animal structure and habits are to be accounted for. How, for instance, could the mammary glands be developed in oviparous creatures? Mr. Darwin regards them as originating in cutaneous glands, developed in the pouch of the marsupials. But his grounds for this statement are very meagre. To a great extent they rest on what an American Naturalist "believes he has seen;" and besides, the ornithorhyncus, which has no pouch, and which is lower in the scale of life than the marsupials, by Mr. Darwin's own admission (O. S., p. 190), possesses the glands. Mr. Mivart's question (Darwin, O. S., p. 189) is a very pertinent one. Another point which this view fails to explain, is the determination of the line of development in particular directions at different periods. At one time it is most marked in fishes, at another in reptiles, at another in mammals. How is this to be accounted for? 4. The experience of cattle-breeders does not warrant the assumption that the principle of natural selection has more than a limited operation. No case has as yet been brought forward in which varieties have been produced which were not capable of interbreeding. Apart from their experience there is not a particle of evidence in favour of the assertion that races which cannot be made to breed together can be descended from a common stock. The unlimited application of this principle is therefore a pure assumption.