SIR,--Your letter of March 14th lingered much on the road, and a long journey before I could answer it, has delayed its acknowledgment till now. I am sorry your enterprise for establishing a factory on the Columbia river, and a commerce through the line of that river and the Missouri, should meet with the difficulties stated in your letter. I remember well having invited your proposition on that subject, and encouraged it with the assurance of every facility and protection which the government could properly afford. I considered as a great public acquisition the commencement of a settlement on that point of the Western coast of America, and looked forward with gratification to the time when its descendants should have spread themselves through the whole length of that coast, covering it with free and independent Americans, unconnected with us but by the ties of blood and interest, and employing like us the rights of self-government. I hope the obstacles you state are not insurmountable; that they will not endanger, or even delay the accomplishment of so great a public purpose. In the present state of affairs between Great Britain and us, the government is justly jealous of contraventions of those commercial restrictions which have been deemed necessary to exclude the use of British manufactures in these States, and to promote the establishment of similar ones among ourselves. The interests too of the revenue require particular watchfulness. But in the non-importation of British manufactures, and the revenue raised on foreign goods, the legislature could only have in view the consumption of our own citizens, and the revenue to be levied on that. We certainly did not mean to interfere with the consumption of nations foreign to us, as the Indians of the Columbia and Missouri are, or to assume a right of levying an impost on that consumption; and if the words of the laws take in their supplies in either view, it was probably unintentional, and because their case not being under the contemplation of the legislature, has been inadvertently embraced by it. The question with them would be not what manufactures these nations should use, or what taxes they should pay us on them, but whether we should give a transit for them through our country. We have a right to say we will not let the British exercise that transit. But it is our interest as well as a neighborly duty to allow it when exercised by our own citizens only. To guard against any surreptitious introduction of British influence among those nations, we may justifiably require that no Englishman be permitted to go with the trading parties, and necessary precautions should also be taken to prevent this covering the contravention of our own laws and views. But these once securely guarded, our interest would permit the transit free of duty. And I do presume that if the subject were fully presented to the legislature, they would provide that the laws intended to guard our