Veterinary Medicines, Their Actions, Uses and DoseKorinek, George Franklyn
Science
Veterinary Medicines, Their Actions, Uses and Dose
Korinek, George Franklyn
Veterinary drugs
ACTIONS AND USES.--A true intestinal antiseptic and antiferment, is also
expectorant, antiseptic and parasiticide. Used in intestinal flatulence,
dissolved in tincture capsicum; in diarrhoea and dysentery, is of great
value in these ailments, quickly allays foul odor of the evacuations of
the bowels; large doses irritate the kidneys and cause bloody urine
which ceases upon withholding the drug. When powdered on a wound as wire
cuts, etc., will keep away flies and other insects, besides it is a
powerful antiseptic and promotes the healing of wounds. Used as an
ointment it is very effective in parasitic skin diseases.
NUX VOMICA--QUAKER BUTTON
The dried ripe seeds of Strychnos nux vomica, yielding when assayed by
the process given below, not less than 1.25 per cent of strychnine.
HABITAT.--The tree is a native of the East Indies, growing in Bengal,
Malabar, on the Coromandel Coast, in Ceylon, in many islands of the
Indian Archipelago, in Cochin-China and in other neighboring countries.
DESCRIPTION.--Orbicular, nearly flat, sometimes irregularly bent, about
three-quarters of an inch in diameter and two in thickness; externally
grayish or greenish-gray, the surface covered with short closely
oppressed, satiny hairs; rounded or somewhat acute at the margin, with a
slight ridge extending from the center of one side to the edge;
internally whitish-gray, horny, very tough, the endosperm in two more or
less regular concavo-convex halves, between which, at one end, lie the
heart-shaped, palmately nerved cotyledons; inodorous; taste intensely
and persistently bitter.
CONSTITUENTS.--Two alkaloids. 1. Strychnine, 0.2-0.6 per cent. 2.
Brucine, 0.5-1.0 per cent. Similar in action to strychnine, but weaker
and slower. Both alkaloids exist in combination with igasuric acid.
Brucine occurs in rectangular octohedral crystals; it is soluble in
alcohol, in 7 parts of chloroform, and possesses a bitter taste. With
sulphuric and nitric acids a beautiful blood-red color is developed.
There are also: 4. Igasuric acid with which strychnine and brucine are
combined. 5. Loganin, an inert glucoside occurring in colorless prisms.
DOSE.--Of the ground seeds, horses and cattle, 1 to 2 dr.; sheep, 20 to
40 gr.; pigs, 10 to 20 gr.; dogs, 1 to 2 gr.
PREPARATIONS
EXTRACTUM NUCIS VOMICAE--EXTRACT OF NUX VOMICA
Made by maceration with alcohol, water and acetic acid; percolation with
alcohol and water and evaporation. Standardized to contain 5 per cent of
strychnine.
DOSE.--Horses and cattle, 5 to 15 gr.; sheep, 2 to 5 gr.; pigs, 1 to 2
gr.; dogs, ¹⁄₈ to ¹⁄₄ gr.
FLUIDEXTRACTUM NUCIS VOMICAE--FLUIDEXTRACT OF NUX VOMICA
Made by digestion and percolation with alcohol and water and acetic
acid. The alcohol is distilled off and the solution evaporated. Alcohol
and water are added so that the fluid extract shall contain one per cent
of strychnine.
DOSE.--Horses and cattle, 1 to 2 dr.; sheep, 20 to 30 m.; pigs, 10 to 20
m.; dogs, 1 to 2 m.
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