Pain in any part of the first zone may be treated and overcome, temporarily at least, and often permanently, by pressure on all surfaces of the first joint of the great toe, or on the corresponding joint of the thumb. Should the pressure be limited to the upper surface of the great toe, the anesthetic or analgesic effects will extend up the front of the body to the fronto-parietal suture--where the bones join on top of the skull. They will also extend across the chest and down the anterior surface of the first zone of the arm and thumb, and often to the thumb side of the index finger. Should pressure be made on the under surface of the great toe, the effects will extend along the first zone in the sole of the foot and up the back of the leg, thigh, body and head in that zone to the above-named suture; also across the back and down the posterior surface of the first zone of the arm and thumb, and frequently the thumb side of the index finger. Firm pressure on the end of the great toe or tip of thumb will control the entire first zone. Firm pressure on the tips of the fingers or toes control individual zones. Lateral or side pressure on thumbs and fingers or toes will affect lateral or side boundaries of the zones pressed, and also transverse extensions to nostrils, lips and ears. A limited amount of anesthesia may often be established by pressure over any resistant bony surface, in any zone compressed, and often the mere momentary contact with the galvanic cautery, or pressure with a sharp-pointed applicator, or with the thumb or finger-nail, will produce the same result. Contacts, especially with aluminum combs or pointed instruments, may be momentary, if frequently repeated, but protracted contacts are often necessary. Prolonged pressure with an aluminum hair comb is fast becoming a popular method, but similar pressures with the nails of the thumbs and fingers are likely the method Nature intended. Pressure with bands of elastic, metal, cloth, or leather on the fingers, toes, wrists and ankles, as well as on the knees and elbows, are often useful in overcoming pain in an individual zone or group of zones. If these pressures are resisted by pathological processes elsewhere in the zone or zones, pain is sometimes excited. In other words, if there is an abscess or some active inflammatory condition present,--as in middle-ear trouble, pressure often aggravates or stimulates the pain to renewed endeavors. It usually however, overcomes the pain momentarily. Zone pressure has, for this reason, become a diagnostic factor of great value in disclosing hidden pus conditions or inflammatory processes--particularly in the roots of teeth, the ears, appendix, ovaries, or in other organs.