"When I received the relations of _resemblance_, _contiguity_, and _causation_, as principles of union among ideas, without examining into their causes, 'twas more in prosecution of my first maxim, that we must in the end rest contented with experience, than for want of something specious and plausible which I might have displayed on that subject. 'Twould have been easy to have made an imaginary dissection of the brain, and have shown why, upon our conception of any idea, the animal spirits run into all the contiguous traces and rouse up the other ideas that are related to it. But though I have neglected any advantage which I might have drawn from this topic in explaining the relations of ideas, I am afraid I must here have recourse to it, in order to account for the mistakes that arise from these relations. I shall therefore observe, that as the mind is endowed with the power of exciting any idea it pleases; whenever it despatches the spirits into that region of the brain in which the idea is placed; these spirits always excite the idea, when they run precisely into the proper traces and rummage that cell which belongs to the idea. But as their motion is seldom direct, and naturally turns a little to the one side or to the other; for this reason the animal spirits, falling into the contiguous traces, present other related ideas, in lieu of that which the mind desired at first to survey. This change we are not always sensible of; but continuing still the same train of thought, make use of the related idea which is presented to us and employ it in our reasonings, as if it were the same with what we demanded. This is the cause of many mistakes and sophisms in philosophy; as will naturally be imagined, and as it would be easy to show, if there was occasion."--(I. p. 88.) Perhaps it is as well for Hume's fame that the occasion for further physiological speculations of this sort did not arise. But, while admitting the crudity of his notions and the strangeness of the language in which they are couched, it must in justice be remembered, that what are now known as the elements of the physiology of the nervous system were hardly dreamed of in the first half of the eighteenth century; and, as a further set off to Hume's credit, it must be noted that he grasped the fundamental truth, that the key to the comprehension of mental operations lies in the study of the molecular changes of the nervous apparatus by which they are originated.