Preston rose, and remarked, in view of it, that he presumed there would be little disposition to transact business; that the event that had just occurred, was an epoch in the legislative history of the nation, and that therefore he would move that the senate adjourn. The motion was adopted unanimously. His resignation as senator did not by any means close his intercourse with his fellow-countrymen. He still labored for his country; and by letters from his residence in Kentucky, and by speeches delivered there and elsewhere, frequently sent forth his opinions on the various topics of the day. The Whig party had long regarded him as their most prominent candidate for the chief magistracy, and he was nominated by acclamation in the convention of 1844, when ‘Justice to Henry Clay,’ was the watchword of the contest. He was defeated, however, by the late James K. Polk, who unexpectedly received the democratic nomination, and remained in retirement until after the election of General Taylor to the Presidency. In compliance with the earnest wishes of his political friends he consented to resume his seat in the senate, and in 1849 was again elected to that honorable position. During the exciting session of 1849–50, all his energies were devoted to securing the passage of the series of measures known as the ‘Compromise Acts,’ and there is no doubt that his incessant and intense labors upon the multifarious schemes which engrossed the attention of congress, occasioned serious debility and hastened his death. When, in the winter of 1850–51, it became but too evident that his disease was gaining the mastery over him, he visited New Orleans and Havana, in the hope that travel and relaxation, united with the effects of change of climate, would renovate his physical system. No ♦permanent advantage, however, resulted from this experiment, and he was again induced, by a consciousness of his failing health, to resign his seat in the senate――the resignation to take effect on the 6th of September, 1852. But he was not destined to see that day. He became gradually weaker and weaker, and was confined to his room in Washington for several weeks, where he breathed his last on the morning of the 29th of June, 1852, at seventeen minutes past eleven o’clock. No one was present at the time, except his son, Thomas Hart Clay, and governor Jones, of Tennessee. His last moments were calm and quiet, and he seemed in full possession of all his faculties, apparently suffering but little. He did not speak for many hours before his dissolution, but his countenance indicated a happy resignation and full knowledge of his condition. He had long previously made every preparation for death, giving his son full instructions as to the disposition of his body and the settlement of his worldly affairs.