In the organization of the general government through all its ramifications he took a deep interest and an active part. Every subject that was presented to Congress for consideration he analyzed with the skill of a sage, a statesman and a philosopher. In 1790, he closed his legislative career and declined again entering upon its arduous duties. Under the act of Congress of 1791, imposing a duty on domestic distilled spirits, Mr. Clymer was appointed to superintend its collection in his own state. The tax was then called, by way of opprobrium, the _excise_. This law gave great dissatisfaction in many places, and in Pennsylvania produced what was termed the _whiskey rebellion_, which required the military to restore order. Unpleasant as it was, Mr. Clymer proceeded to perform his duty by appointing the required collectors in each county, endeavouring to persuade the people to submit to the law whilst in force, and pursue the constitutional remedy for its repeal if they believed it wrong. During the height of the excitement he hazarded his life among the malecontents where but few other men would have been spared if clothed with the same office. He finally resigned this station, and was soon after appointed a commissioner, with Colonels Pickens and Hawkins, to negociate a treaty with the Cherokee and Creek Indians in Georgia, which was effected on the 29th of June, 1796, and closed his long, faithful and arduous public career. He had perilled his life, his fortune and his sacred honour for his country; he had been her unyielding and fearless advocate amidst the storms of revolution, civil discord and open rebellion; he now saw her peaceful, prosperous and happy, with the illustrious Washington presiding over her destinies. He could therefore retire to enjoy the fruits of his labours and his toils, without any to disturb or make him afraid.