When Paul spoke of the second coming of Christ, in his first epistle to the Thessalonians, they understood that it was an event then imminent. The apostle, in his second epistle, corrects this impression, by referring to the foregoing prediction in Daniel, which must be previously fulfilled. He assures them that “the day of Christ” “shall not come, except there be” an apostasy, or “a falling away first, and that Man of Sin,” or the lawless one, “be revealed, the son of perdition; who opposeth and exalteth himself above all that is called God, or that is worshipped; so that he, as God, sitteth in the temple of God, showing himself that he is God. Remember ye not, that when I was yet with you, I told you these things? And now ye know what withholdeth that he might be revealed in his time. For the mystery of iniquity doth already work: only he who now letteth will let, until he be taken out of the way. And then shall that Wicked be revealed, whom the Lord shall consume with the spirit of his mouth, and shall destroy with the brightness of his coming,” 2 Thess. 2:2-8. The uniform application of these predictions to the Papacy, by Protestant writers, renders it unnecessary to argue this point. That power began early to be manifested, but its full development was “let,” _i.e._, hindered, by the continuance of the Western empire, which had to be taken out of its way. Tertullian, near the close of the second century, in expounding those words, says: “Who can this be but the Roman state, the division of which into ten kingdoms will bring on Antichrist?” And he gives as a reason why the Christians of his time prayed for the Roman empire: that _the greatest calamity hanging over the world was retarded by the continuance of it_. Cyril of Jerusalem in the fourth century applied the passage in the same manner, and says: “Thus the predicted Antichrist will come when the times of the Roman empire shall be fulfilled, and the consummation of the world shall approach. Ten kings of the Romans shall arise together, in different places indeed, but they shall reign at the same time. Among these the eleventh is Antichrist, who, by magical and wicked artifice, shall seize the Roman power.” A large number of the ancient fathers interpreted this text in the same manner. In A. D. 257, 1260 years before the time of Luther, Stephen, Bishop of Rome, began to act the pope in good earnest,—excommunicating those who dissented from the doctrines of Rome. In 312, 1260 years before the massacre of St. Bartholomew in 1572, Constantine became Emperor of Rome, embraced Christianity, and terminated the last and bloodiest of the Pagan persecutions—that of Diocletian, which had continued ten years. Constantine undertook to remodel the church, in conformity to the government of the state, and the unhallowed union of the two resulted in the dignities of patriarchs, exarchs, archbishops, canons, prebendaries, &c., which he endowed with wealth and worldly honors.