_Grand Direct._ VIII. Remember that you are related to Christ as the Physician of your souls, and to the Holy Ghost as your Sanctifier. Make it therefore your serious study, to be cured by Christ, and cleansed by his Spirit, of all the sinful diseases and defilements of your hearts and lives. Though I did before speak of our believing in the Holy Ghost, and using his help for our access to God, and converse with him; yet I deferred to speak fully of the cleansing and mortifying part of his work of sanctification till now; and shall treat of it here, as it is the same with the curing work of Christ, related to us as the Physician of our souls: it being part of our subjection and obedience to him, to be ruled by him, in order to our cure. And what I shall here write against sin, in general, will be of a twofold use. The one is, to help us against the inward corruptions of our hearts, and for the outward obedience of our lives, and so to further the work of sanctification, and prevent our sinning. The other is, to help us to repentance and humiliation, habitual and actual, for the sins which are in us, and which we have already at any time committed. The general directions for this curing and cleansing of the soul from sin, are contained, for the most part, in what is said already: and many of the particular directions also may be fetched from the sixth direction before-going. I shall now add but two general directions, and many more particular ones. _Direct._ I. The two general directions are these: 1. Know what corruptions the soul of man is naturally defiled with: and this containeth the knowledge of those faculties, that are the seat of these corruptions, and the knowledge of the corruptions that have tainted and perverted the several faculties. _Direct._ II. 2. Know what sin is, in its nature or intrinsic evil, as well as in the effects. [Sidenote: How the several faculties of the soul are corrupted and diseased.] [Sidenote: In what cases sound understanding may be ignorant.]