A.D. 1723, yellow pestilence prevailed in many parts of Spain, especially in the cities on the coast. Lisbon also suffered from pestilence, the predominant symptom of which was black vomit. Miliary fever prevailed at Frankfort on the Maine. Don Vincente Boibid, a celebrated physician of Madrid, published a work entitled ‘Breve Reflexion ό crisis medica sobre el Dolor Colico, con animo de remediar tan continuos y largos tormentos como suele excitar quando molesta por medio de un anticolico especifico, que le vence en media hora: y á veces en una.’ This physician attributed the pestilence prevalent in Spain to the use of fruit and snow-water. The year following, epidemic catarrh prevailed chiefly amongst children in the principality of the Asturias. Palermo was nearly destroyed by an earthquake; 6000 persons perished. From this period unto 1727, malignant fevers prevailed all over Europe and America. Louis, king of Spain, died this year from small-pox, as did also the Duchess of Bedford. In the latter year, inoculation was practised on criminals. A.D. 1726, a series of anomalous diseases was prevalent in Granada, and caused great mortality. Leprosy began to spread in the city of Lebrija, in Andalusia; it lasted until 1764. About this period a severe earthquake shook Palermo in September, and upwards of 6000 persons were buried in the ruins. A.D. 1727, epidemic mania prevailed in Spain. Dr. Casal makes mention of its having carried off many members of the Council of Pilona. Carthage was visited by pestilence, similar to that which prevailed in the year 1637. A.D. 1728, influenza was epidemic in Spain: it was named by Pedro de Rotundis, ‘un catarro sufocativo.’ Yellow fever was very fatal to the inhabitants of Charleston, United States: it was termed ‘a bilious plague,’ from its severity. A similar disease carried off great numbers of the population of Carthagena and Portobello, in South America: the most fatal symptom was black vomit. This disease made great havoc among the crews of the vessels under Don Domingo Justiniani, and of the galleons under Lopez Pintado. Epidemic pestilence was rife in Poland, Austria, and Siberia. The island of Bourbon, as described by Don Ulloa, was afflicted with plague, as was also Tripoli, Damascus, and Aleppo. Scarlet fever raged in Edinburgh, and chincough in England. About this period, miliary fever, or sweating pestilence, prevailed, with great mortality, at Chambery, Annecy, St. Jean de Maurienne (Savoy), at Carmagnola, Vercelli, Ivrea, and Biella. The seven following years, 1729–1735, pestilence raged in Vienna, Pignerol, Fossano, Nizza, Rivoli, Asti, Larti, Acqui, Basle, Silesia, Thrasburg (Lower Rhine), Trino, Frésneuse (Lower Seine), Vimeux (Seine-et-Oise), Orleans (Loiret), Plouviers (Loiret), Meaux, Villeneuve, St. George (Seine et Maine), Bohemia, Denmark, Sweden, and Russia.