A.D. 1778, an earthquake did much harm at Smyrna on the 3rd of July. This same year, after the British army had vacated the city of Philadelphia, United States, bilious, yellow, or remittent fever prevailed to a great extent amongst the inhabitants. The plague was rife at Constantinople; an epidemic angina ravaged Manchester and various other parts of England, and the city of Carthagena in Spain again suffered from pestilence, similar to that which was observed A.D. 1771; it continued, in fact, in an aggravated form, the following years until 1779, and caused great mortality. A.D. 1780, the winter was severe, both in Europe and America. In England, on the 14th of January, the mercury fell 26° below zero, and in Glasgow 46° below the same point. The summer of this year was very hot; bilious remittent fevers raged in Philadelphia and in other parts of the States; a ‘break-bone fever,’ as it was called, also prevailed extensively, but was not fatal. The thermometer at times stood at 102°. At this time cholera prevailed in the East Indies, and is reported to have carried off at Hurdwar, during a festival which is annually held there, some 20,000 persons, and during the following year, 1781, to have assailed, in its most malignant form, a division of the Bengal troops stationed at Garigani. During the summer of 1780, epidemic pestilence broke out in various parts of Spain: it first made its appearance in a village of Passages in the month of May, and continued for some time; it was supposed to have arisen from intramural burial, the stench from the overcrowded graveyards being intolerable. The burning heats, this year, may be said to have caused much suffering in several parts of Europe, there having been scarcely any rain; the summer having been succeeded by a heavy, cloudy winter, predisposed the inhabitants of various parts of Europe to catarrhal fevers: pernicious epidemics also prevailed in many parts of Spain; and a malignant fever was rife amongst the inhabitants of Pampeluna: the city of Olite was also similarly affected; after a time it extended to Bericayú, Andosella, Mendaira, Toledo, Vidaurreta, and other cities and places. In Pampeluna it persisted for six years, until 1787. A disease termed ‘Andalusian fever’ prevailed this year in South America among the Spanish colonists, and also at Rio de Janeiro and other Brazilian settlements. At Tauris, 15,000 dwellings were demolished, and vast multitudes were swallowed up by an earthquake.