These facts harmonize with those observed in Paris. The malady commenced with symptoms of coryza, attended by cough and snuffling; dyspnea, with severe bronchial irritation, supervened, when the paroxysm all at once became greatly aggravated. One symptom was remarked as being pretty general and prominent, viz., a feeling of lassitude and fatigue of the limbs, with more or less great moral prostration: the disease was not very fatal, and generally lasted for eight or ten days. During this period an extraordinary epidemic prevailed at a village called Mandroros, in Russia,--gangrene of the spleen. From the singular nature of this disease, a description will probably be found interesting. It commenced without any premonitory symptoms; the patient was suddenly seized with a feeling of burning at the pit of the stomach, accompanied by an insupportable pain in the left hypochondria; lassitude, with vomiting of a greenish bitter fluid, bowels naturally active, urine scanty, loss of appetite, and laborious respiration. Putrid appearances supervened in the course of a few hours, followed by meteorismus, borborygmi, yellowness of the skin, and of the scleroticæ; facies Hippocratica, cramps, cold extremities, and death. This disease, it is said, was not contagious, but epidemic, and it is further stated to have resembled that which was called ‘the plague of Siberia.’ After death, decomposition of the corpses took place rapidly, a black spot first appearing over the splenic region. Necrotomy showed the spleen in an engorged and gangrenous condition.