A.D. 1582, an earthquake was felt at Peru for 500 leagues, some time after the city of Arequipa was overthrown. Pestilence continued to prevail in various provinces of Spain the following year, 1583, with carbuncles, anginas, &c. Francisco Valles speaks of leprosy in his work entitled ‘De iis quæ scripta sunt phisice in libris sacris, sive de sacra philosophia.’ Plague, famine, and war destroyed numbers, this year, in Flanders, and epidemic pestilence ravaged Moravia, and was rife in London, Germany, and Holland. Egypt and Rome also suffered from famine and disease. A.D. 1585 and 1586, the winters were severe, and the summers dry and hot; famine ensued; universal catarrh with general pestilence followed, and prevailed all over Europe. The plague raged at Narva and Revel, in Livonia, in the Gulf of Finland, 59° of north latitude: 6000 persons died at Revel. Thuanus considered that the disease arose from the effects of war and the inclemencies of the weather--“a belli incommoditationibus et cœli inclementiâ.” In the archbishopric of Toledo small-pox broke out: the disease was remarkable, inasmuch as almost all who were attacked were old persons, according to Andres de Leon; ‘en su practico de morbo Gallico.’ Plague raged in Dresden in both these years. On the 9th of July in the latter year, 1586, a severe earthquake was felt, which shook Lima, and ran 170 leagues along the coast, and 50 leagues across the mountainous parts. A.D. 1587, epidemic small-pox broke out in the city of Madrid: 5000 persons and upwards died of it in a short time. The two following years, 1588 and 1589, a pestilence, similar to that of 1583, appeared, and lasted three years: it committed frightful devastation in Seville and its neighbourhood. In the latter year, plague prevailed in Barcelona, and lasted from June to December; it was supposed to have been imported from France. A.D. 1590. A comet was seen this year during the reign of Philip II. The city of Valladolid was attacked with petechial pestilence. The celebrated Francisco Valles de Covarrubias depended principally on local depletion by means of cupping-glasses for its treatment. A dispute arose this year among the Italian physicians as to the virtue of blisters in the treatment of the plague which was prevailing there. During the summer of 1592 the drought was extreme, and the autumn was sultry and variable. The river Thames was fordable at London, and epidemic pestilence destroyed 18,000 persons in that city. Various other parts of England also suffered from it, especially Shropshire, where it was very fatal. The city of Dresden suffered from plague in this and the preceding year, 1591.