A.D. 1616, Germany was greatly troubled with epidemic agues. Two years after, violent tempests, inundations, volcanic eruptions, meteors, &c. distinguished this pestilential period or season. A malignant angina prevailed at Naples: the plague infested Bergen, Norway, Denmark, Egypt, the Levant, and many other places; and a terrible yellow pestilence, in both North and South America, swept away thousands of the Aborigines (Indians). Hutchison says, that the Massachusetts tribe in North America, consisting of 30,000 persons, was reduced to 300! Gorges writes, that the disease occurred in the summer and autumn for several years, commencing A.D. 1618, and ending in 1623. This distemper the Indians described as a spotted putrid fever, with ulcers, and yellowness of the skin and eyes, and bleeding from the mouth and ears. This pestilence must have been of domestic origin, as no known intercourse had been held with any part of this new continent; it evidently was endemic--a bilious pestilence. A.D. 1617, a terrible inundation occurred in Catalonia in Spain, from continued heavy rains, during which more than 50,000 persons lost their lives: the year following, a comet appeared. From this time until 1623, Malta, Naples, Hungary, France, and England suffered from epidemic diseases, such as small-pox, plague, &c. Seville was visited by gangrenous sore-throat about this time; and in 1619, many places in the Levant suffered from epidemic pestilence. In 1620, Antonio de Fonseca, a Portuguese physician of the city of Lisbon, wrote a work entitled ‘De Epidemiâ febrili, grassante in exercitû Regis Catholici in inferiori Palatinato.’ During this year a heavy snow-storm was experienced, which continued for thirteen nights and days; upwards of 20,000 sheep in one district, Eskdale Moor, were destroyed by it and famine conjoined. A.D. 1622, London was visited by epidemic pestilence, which continued for four years. In the first year there died 8000; in the second, 11,000; in the third, 12,000; and in the fourth, 35,417. Plague also broke out about this period in Amsterdam, and persisted, as it is stated, eight years. Pestilence was prevalent in many parts of Spain. In July, the Council of One Hundred, at Barcelona, received advice that pestilence had broken out at Argel; orders were given, in consequence, for the exclusion of all slaves and goods coming thence. A.D. 1625, plague broke out in London, and raged with varied intensity all over England; 30,000 persons were carried off by it in London alone. Epidemic disease also prevailed in Italy, Denmark, and Egypt. Inundations occurred in Spain. In the month of January, the river Tormes departed from its bed, destroying cattle and houses in Salamanca. Seville suffered similarly from the overflowing of the Guadalquivir; and in the year following, 1626, pestilence carried off 60,000 persons at Lyons. France continued to suffer from pestilence the two following years.