Dr. Wollaston’s inquiries were very minute; he was told that in about four, five, or six days, the diseased leg became somewhat less painful, and gradually turned black, appearing at first covered with spots as if it had been bruised; then commenced the affection of the other leg, with the same excruciating pains, and in a few days thereafter that also began to mortify: in a very little time both legs were perfectly sphacelated: the mortified parts separated from the sound spontaneously, the attending surgeon having in most of the cases no other trouble than merely to saw through the bone, with little or no pain to the patient: the separation took place generally about two inches below the knee; in some, rather lower, and in one instance the feet separated at the ankles without any surgical aid; in others the separation was less perfect. The eldest girl had one leg taken off, and the other was entirely sphacelated, but the surgeon delayed removing it, owing to a large abscess which had formed under the hamstrings, attended with a swelling of the thigh. The mother’s right foot came off at the ankle-joint, while the other leg, wasted to the bone, was black and extremely fœtid, what little remained of flesh being quite putrid and almost dried. In one child alone was one of the legs saved, but with the loss, however, of two toes even from that. Three of the children lost both legs, and another child both its feet. The father was attacked about two weeks after the rest of the family, but in a slighter degree, the pain being confined to two fingers of his right hand, which turned blackish and withered for some time, but then got better, and he recovered the use of them. It is remarkable that during the time of this dreadful calamity the whole family are said to have appeared well in some respects; that is to say, they ate heartily, and even slept well when the pain began to abate. When Dr. Wollaston saw them, they all seemed free from febrile symptoms, except the girl already mentioned, who had an abscess in the ham. The mother looked emaciated, and had but very little use of her hands. The rest of the family seemed well; one poor boy in particular looked as healthy and florid as possible, and was sitting on his bed, quite jolly, drumming with his stumps! On inquiry, it was evident that this disease proceeded from eating bread made from spoiled wheat. Another labouring man, who had eaten of the same bread, was affected with a numbness in both hands for about four weeks from the 9th of January: they were continually cold, and the skin peeled off his fingers’ ends: one thumb, he says, remains without any sensation. A nurse who had lived with them from the beginning of their illness was not affected.