A.D. 1642, in the month of January, heavy rains fell continuously for sixteen days at Seville, during which time the Guadalquivir overflowed its banks, destroying much property in Castile, as also many of the inhabitants. The settlers at Newhaven, in the United States of America, and those on the banks of the Delaware river, suffered from pestilence, during this year. In the subsequent year, the city of Boston suffered from epidemic disease, as did also many other parts of the States. A malignant fever broke out in the army of the Earl of Essex, whilst besieging Reading, in England; the king’s army also suffered. Great numbers in both armies having died, it ultimately extended to Oxford and to all the villages within ten miles. It first appeared like a putrid synochus; after the middle of summer it raged with increased violence and in a greatly aggravated form; spots began to appear and pustules, attended with great prostration of strength; many had buboes as in the true plague. During the dog-days the disease was considered and treated as a mild form of plague. A.D. 1644, epidemic malignant disease broke out at Madrid, causing great mortality. Denmark and England also suffered from malignant fevers, which were followed by dysentery. The preceding summer had been excessively hot, and there were also heavy and frequent showers, with dews at night. A.D. 1646, inundations took place in Holland, in Zealand, and in Friesland. Earthquakes were felt in many parts of the world; in Chili, several mountains of the Andes sunk into the earth, one after another. A comet was seen about this period. The ravages of locusts were great during this and the two subsequent years. Pestilence caused great destruction in Andalusia: plague raged in London, extending to other parts of the kingdom, especially to Newark, Stafford, and Totnes. About the same time it likewise occasioned great mortality in Ireland. Epidemic catarrh prevailed in America, affecting equally the Dutch, English, and Swiss colonists. Pestilential yellow fever was rife throughout the West Indies, especially in Barbados and St. Kitts; it has been computed that in the two islands 12,000 perished. Various parts of Spain suffered from epidemic pestilence during this and the following years: the city of Valencia suffered great mortality from an epidemic; it was of so general a character, that it seized on old and young.