The city of Carmona was visited by epidemic pestilence, as was also the neighbouring country. The disease which pervaded Andalusia soon spread with great mortality through the populations of Catalonia, Aragon, and Valencia. In the month of February the Council of One Hundred (Ciento) of Barcelona were occupied with the pestilence which was ravaging Tortosa. In May the same Council declared Gerona to be in a pestilential condition. The year following, 1651, the city of Huesca, as also Alcubierre and a greater part of the population of Aragon, suffered from pestilence of rather a formidable character. Barcelona soon became affected; the disease raged there with extreme violence. Dr. Salvador wrote a work describing this pestilence: it was entitled ‘Breve Tratado de la Peste y fiebre pestilente, en el qual se trata de su esencia, causas, dignocion, preservacion y purificacion.’--A.D. 1652, a comet was seen. A.D. 1653. In Girona, at present called Gerona y Osterlique, pestilence broke out, and raged with violence. The year following, 1654, epidemic disease again made its appearance in England and also in Denmark. In the month of April it broke out in Chester in England. Pestilential disease at this period was also rife in Turkey, Russia, Presburg, Hungary, Italy, Egypt, Malta, Sardinia, Leyden, Riga, and Amsterdam: 200,000, it is stated, died from it in Moscow alone, 9000 in Riga, 13,200 at Amsterdam, and 13,000 at Leyden. Two years after (1656), 240,000 persons were destroyed by mortal pestilence in Naples; a great number--9000--in Benevento, 10,000 at Genoa, the like number at Rome, and in the Neapolitan territories generally it is supposed 400,000 perished. Cardinal Gastaldi, speaking of the pestilence at Rome, states that it was one of the most horrible diseases Rome had ever suffered from. The same author eulogizes the precautionary measures adopted by the Spaniards and the Portuguese. Franco, a physician of Carmona, in his work entitled ‘Elysius jucundarum Quæstionum Campus medicis imprimis utilis,’ lauds as great alexipharmics the properties of the unicorn and of the bezoar concretion.