“When that thy highness and thy great power is vexed and troubled with divers sickness, and thy lordships and almost the middle part of thy realm with the venomous fever of pestilence, and, by the reason of that, young and old and of all manner of ages, with divers wailings and sadness they are stricken: therefore, excellent and noble prince, we are moved with every love and duty, and not for no lucre neither covetyse, to ordain a short governing against this foresaid fever[489].” The Second Sweat in 1508. After the first outburst of the sweat in 1485 had subsided, probably before winter was well begun, nothing more is heard of it for twenty-three years. It reappeared in 1508, a third time in 1517, a fourth time in 1528, and for the last time in 1551. With each successive outbreak, our information becomes less meagre, while the epidemic of 1551 actually called forth an English printed book by Dr Caius, the epidemic of 1528 having called forth a whole crop of foreign writings on its spreading to the continent (for the first and only time) in the year following (1529). As the nature, causes, and favouring circumstances of the sweat cannot profitably be dealt with except on a review of its whole history, it will be necessary to take up at once and together the four subsequent epidemics of it in this country, leaving the intercurrent and probably much more disastrous epidemics of bubo-plague, during the same period, as well as the great invasion of syphilis in 1494-6, to be chronicled apart.