The first that we hear of attempts at isolation and notification is in 1518. In April of that year, the Court being in Berkshire or Oxfordshire, Sir Thomas More charged the mayor of Oxford, and the commissary, in the king’s name “that the inhabitants of those houses that be, and shall be infected, shall keep in, put out wispes, and bear white rods, as your Grace devised for Londoners[603].” By his Grace is to be understood the king himself; and these measures devised by him--the keeping in, the putting out of wisps on the houses, and the carrying of white rods,--might have been tried as early as the epidemic of 1513, which was a severe one. When two of the Venetian ambassador’s servants died of the plague in 1513, their bed, sheets and other effects were thrown into the river. On the 21st of May, 1516, the ambassador removed to Putney owing to a case of plague in his house, and he was not allowed to see cardinal Wolsey until the 30th of June, i.e. until forty days had elapsed. This is perhaps the first mention of the quarantine which the Court rigorously put in practice against those who had business with it. On the 22nd July, 1518, the same ambassador wrote to Venice from Lambeth that two of his servants had lately died of the plague; and, on the 11th August, again from Lambeth, that the king and Wolsey would not see him because of the plague; “but on the expiration of forty days, which had nearly come to an end, he would not fail to do his duty as heretofore.” On the 25th August, 1535, Chapuys, in a letter to Charles V., gives an amusing account of an attempt made by the French ambassador to see Henry VIII. and Cromwell on diplomatic business. The Court was residing in Gloucestershire owing to plague in and near London (it was at Bristol also), and the ambassador journeyed thither to carry his business through. However he went no nearer than six miles, because a “French merchant” who followed him died upon the road of the plague, as it was feared. The king asked him to put his charge in writing, but the ambassador replied that he had orders to tell it in person, and that he could wait. At length he lay in wait for Secretary Cromwell in the fields where he went to hunt with the dukes of Norfolk and Suffolk, and delivered his charge despite the manifest unwillingness of Cromwell, who came away from the improvised diplomatic interview in no good humour. The first plague-order of which the full text is extant was issued in the 35th of Henry VIII. (1543). As it contains the germs of all subsequent preventive practice, I transcribe it in full[604]. “35 Hen. VIII. A precept issued to the aldermen:--That they should cause their beadles to set the sign of the cross on every house which should be afflicted with the plague, and there continue for forty days: