Queen Elizabeth and her Council were baffled by the persistence of plague in London in 1581-82-83; the infection pursued its own course despite all efforts to “stamp it out,” so that the letters from the lords of the Council to the mayor begin to assume a somewhat querulous and impatient tone[634]. To a letter of remonstrance, 21st September, 1581, the mayor replied next day that every precaution had been taken. On the 22nd March, 1582, the mayor retorted upon the Court that an artificer in leather, dwelling near Fleet Bridge, had the plague in his house, that his house had been shut up, and he restrained from going out; nevertheless he had access to the Court in the things of his art, both for the queen and her household. On the 1st September, 1582, the plague having greatly increased as appeared by certificate of the number of the dead during the last week, the Privy Council informed the mayor that this was in part “by negligence in not keeping the streets and other places about the city clean, and partly through not shutting up of the houses where the sickness had been found, and setting marks upon the doors; but principally through not observing orders for prevention of the infection heretofore sent to them by the Council.” The mayor sent answer the same day that every care had been taken: the streets had been cleansed every other day; the parish clerks had been appointed to see to the shutting up of infected houses, and putting papers upon the doors; he had also appointed some of his own officers to go up and down the city to view and inform him whether these things had been done.