Hippocrates was born at Cos, about 460 B.C., but spent most of his life at Larissa, in Thessaly. He was educated as a physician by his father, and travelled extensively as an itinerant practitioner for several years. His travels in different climates and among many different people undoubtedly tended to sharpen his keen sense of observation. He was a practical physician as well as a theorist, and, withal, a clear and concise writer. "Life is short," he says, "opportunity fleeting, judgment difficult, treatment easy, but treatment after thought is proper and profitable." His knowledge of anatomy was necessarily very imperfect, and was gained largely from his predecessors, to whom he gave full credit. Dissections of the human body were forbidden him, and he was obliged to confine his experimental researches to operations on the lower animals. His knowledge of the structure and arrangement of the bones, however, was fairly accurate, but the anatomy of the softer tissues, as he conceived it, was a queer jumbling together of blood-vessels, muscles, and tendons. He does refer to "nerves," to be sure, but apparently the structures referred to are the tendons and ligaments, rather than the nerves themselves. He was better acquainted with the principal organs in the cavities of the body, and knew, for example, that the heart is divided into four cavities, two of which he supposed to contain blood, and the other two air. His most revolutionary step was his divorcing of the supernatural from the natural, and establishing the fact that disease is due to natural causes and should be treated accordingly. The effect of such an attitude can hardly be over-estimated. The establishment of such a theory was naturally followed by a close observation as to the course of diseases and the effects of treatment. To facilitate this, he introduced the custom of writing down his observations as he made them--the "clinical history" of the case. Such clinical records are in use all over the world to-day, and their importance is so obvious that it is almost incomprehensible that they should have fallen into disuse shortly after the time of Hippocrates, and not brought into general use again until almost two thousand years later. But scarcely less important than his recognition of disease as a natural phenomenon was the importance he attributed to prognosis. Prognosis, in the sense of prophecy, was common before the time of Hippocrates. But prognosis, as he practised it and as we understand it to-day, is prophecy based on careful observation of the course of diseases--something more than superstitious conjecture.