Coupled with the new method of physical diagnosis in the effort to substitute knowledge for guess-work came the studies of the experimental physiologists--in particular, Marshall Hall in England and Francois Magendie in France; and the joint efforts of these various workers led presently to the abandonment of those severe and often irrational depletive methods--blood-letting and the like--that had previously dominated medical practice. To this end also the "statistical method," introduced by Louis and his followers, largely contributed; and by the close of the first third of our century the idea was gaining ground that the province of therapeutics is to aid nature in combating disease, and that this may often be accomplished better by simple means than by the heroic measures hitherto thought necessary. In a word, scientific empiricism was beginning to gain a hearing in medicine as against the metaphysical preconceptions of the earlier generations. PARASITIC DISEASES I have just adverted to the fact that Napoleon Bonaparte, as First Consul and as Emperor, was the victim of a malady which caused him to seek the advice of the most distinguished physicians of Paris. It is a little shocking to modern sensibilities to read that these physicians, except Corvisart, diagnosed the distinguished patient's malady as "gale repercutee"--that is to say, in idiomatic English, the itch "struck in." It is hardly necessary to say that no physician of today would make so inconsiderate a diagnosis in the case of a royal patient. If by any chance a distinguished patient were afflicted with the itch, the sagacious physician would carefully hide the fact behind circumlocutions and proceed to eradicate the disease with all despatch. That the physicians of Napoleon did otherwise is evidence that at the beginning of the century the disease in question enjoyed a very different status. At that time itch, instead of being a most plebeian malady, was, so to say, a court disease. It enjoyed a circulation, in high circles and in low, that modern therapeutics has quite denied it; and the physicians of the time gave it a fictitious added importance by ascribing to its influence the existence of almost any obscure malady that came under their observation. Long after Napoleon's time gale continued to hold this proud distinction. For example, the imaginative Dr. Hahnemann did not hesitate to affirm, as a positive maxim, that three-fourths of all the ills that flesh is heir to were in reality nothing but various forms of "gale repercutee."