In the forty odd years that have elapsed since this pioneer observation of Bernard, numerous facts have come to light showing the extreme importance of such intermediate alterations of food-supplies in the blood as that performed by the liver. It has been shown that the pancreas, the spleen, the thyroid gland, the suprarenal capsules are absolutely essential, each in its own way, to the health of the organism, through metabolic changes which they alone seem capable of performing; and it is suspected that various other tissues, including even the muscles themselves, have somewhat similar metabolic capacities in addition to their recognized functions. But so extremely intricate is the chemistry of the substances involved that in no single case has the exact nature of the metabolisms wrought by these organs been fully made out. Each is in its way a chemical laboratory indispensable to the right conduct of the organism, but the precise nature of its operations remains inscrutable. The vast importance of the operations of these intermediate organs is unquestioned. A consideration of the functions of that other set of organs known collectively as the nervous system is reserved for a later chapter. VI. THEORIES OF ORGANIC EVOLUTION GOETHE AND THE METAMORPHOSIS OF PARTS When Coleridge said of Humphry Davy that he might have been the greatest poet of his time had he not chosen rather to be the greatest chemist, it is possible that the enthusiasm of the friend outweighed the caution of the critic. But however that may be, it is beyond dispute that the man who actually was the greatest poet of that time might easily have taken the very highest rank as a scientist had not the muse distracted his attention. Indeed, despite these distractions, Johann Wolfgang von Goethe achieved successes in the field of pure science that would insure permanent recognition for his name had he never written a stanza of poetry. Such is the versatility that marks the highest genius. It was in 1790 that Goethe published the work that laid the foundations of his scientific reputation--the work on the Metamorphoses of Plants, in which he advanced the novel doctrine that all parts of the flower are modified or metamorphosed leaves. "Every one who observes the growth of plants, even superficially," wrote Goethe, "will notice that certain external parts of them become transformed at times and go over into the forms of the contiguous parts, now completely, now to a greater or less degree. Thus, for example, the single flower is transformed into a double one when, instead of stamens, petals are developed, which are either exactly like the other petals of the corolla in form, and color or else still bear visible signs of their origin.