It may be assumed as a matter of course that the king had no power to dismiss an inquisitor-general who held his commission at the pleasure of the pope, but the sovereign had usually abundant means of enforcing a resignation. Whether that of Alfonso Suárez de Fuentelsaz, in 1504, was voluntary or coerced is not known, but the case of Cardinal Manrique, the successor of Adrian, shows that if an inquisitor-general was not forced to resign he could be virtually shelved. Manrique, as Bishop of Badajoz, after Isabella's death, had so actively supported the claims of Philip I that Ferdinand ordered his arrest; he fled to Flanders, where he entered Charles's service and returned with him to Spain, obtaining the see of Córdova and ultimately the archbishopric of Seville.[763] Perhaps he incurred the ill-will of the Empress Isabella soon after his appointment, for we find him complaining, January 23, 1524, to Charles that when in Valencia she had ordered the disarmament of the familiars and the arrest of Micer Artes, a salaried official of the Inquisition, violations of its privileges for which he asked a remedy.[764] In 1529, he gave more serious cause of offence. When Charles sailed, July 28th, to Italy for his coronation, he placed under charge of the empress Doña Luisa de Acuña, heiress of the Count of Valencia, until her marriage should be determined. There were three suitors--Manrique's cousin the Count of Treviño, heir apparent of the Duke of Najera, the Marquis of Astorga and the Marquis of Mayorga. The empress placed her ward in the convent of San Domingo el Real of Toledo, where Manrique abused his authority by introducing his cousin; an altar had been prepared in advance and the marriage was celebrated on the spot. The empress, justly incensed, ordered him from the court to his see until the emperor should return and turned a deaf ear to the representations by the Suprema, December 12th, of the interference with the holy work of the Inquisition and the discredit cast upon it. It was probably to this that may be referred the delay in his elevation to the cardinalate, announced March 22, 1531, after being kept _in petto_ since December 19, 1529. On Charles's return, in 1533, he was allowed to take his place again, but he fell into disgrace once more in 1534, when he was sent back to his see where he died at an advanced age in 1538. Still, this was not equivalent to dismissal; he continued to exercise his functions and his signature is appended to documents of the Inquisition at least until 1537.[765] Yet while thus dealing with the inquisitor-general the crown could exercise no control over the tribunals. The empress was interested in the case of Fray Francisco Ortiz, arrested April 6, 1529, by the tribunal of Toledo, and she twice requested the expediting of his trial for which, October 27, 1530, she alleged reasons of state, but the tribunal was deaf to her wishes as well as to those of Clement VII who