Inquisition and we shall see what stern measures Ferdinand found necessary for their suppression. Yet Ferdinand was justified and the curia was self-condemned for, when the Roman Inquisition was reorganized and found its operations similarly impeded by the letters of the Penitentiary, it ordered, September 26, 1550, its subordinates to pay no attention to them.[282] Meanwhile the struggle continued in Spain. Isabella applied in 1482 to Sixtus to give her inquisitors power to pronounce final judgements that should not be subject to revision or appeal. He replied, February 23, 1483, that he would take counsel with the Sacred College, the result of which was a bull of May 25th, in which he conferred on Iñigo Manrique, Archbishop of Seville, appellate jurisdiction from the inquisitors, deputizing him in place of the pope for the Spanish dominions.[283] This expedient brought no relief to the Conversos. The inquisitors paid no respect to it and would-be appellants found that it was not safe to go to Seville for revision of their cases by the archbishop. It was the same with the letters of absolution that continued to be issued; they were disregarded and many fugitives who had procured them found on their return that they had been burnt in effigy during their absence and that the document on which they relied was of no avail. They needed something more and Sixtus was nothing loath to grant it. As early as August 2nd, he followed the bull of May 25th with another, for which we may safely assume that the Conversos paid roundly, for in it he evoked to Rome all pending cases of appeal, he ordered the Spanish bishops to protect at all hazards the bearers of papal letters of absolution, even to the invocation of the secular arm, and he entreated Ferdinand and Isabella to show mercy to their subjects as they hoped for mercy from God.[284] [Sidenote: _STRUGGLES WITH THE CURIA_]