Meanwhile the popes continued to propitiate Charles's growing power by granting, with as much facility as ever, what was nominally exclusive appellate jurisdiction to the inquisitor-general. In 1523, Adrian VI, as we have seen, confirmed in favor of Manrique the bulls of Sixtus IV and Alexander VI. Clement VII went even farther for, in a bull of January 6, 1524, he not only evoked all pending cases and committed them to Manrique but decreed that any commissions which he might thereafter issue should be invalid without the express assent of Charles, while all appeals were to be made to the inquisitor-general and not to the Holy See, and this he repeated, June 16, 1525. Still appeals continued to be made to Rome and briefs to be granted requiring repeated confirmations of the bulls of 1524 and 1525 with inclusion of the letters obtained in the interval, of which we have examples in 1532 and 1534.[335] Charles was thus justified in enforcing Ferdinand's pragmática of 1509, as when, in 1537, he ordered the corregidor of Murcia to prevent the publication of certain letters understood to have been procured from the pope against the Inquisition; if presented they were to be sent to the Council of Castile for its action, and parties endeavoring to use them were to be arrested and dealt with as might be deemed most advantageous to the Holy Office.[336] The position of Charles, as the master of Italy and the protagonist of the Church in its struggle with Lutheranism, had thus enabled him to obtain for the Inquisition virtual, though not acknowledged, independence of Rome. There is a very striking illustration of this, in 1531, when Clement VII intervened in favor of Fray Francisco Ortiz, a celebrated Observantine preacher, prosecuted for audaciously criticizing the Inquisition from the pulpit. He had lain in prison for more than two years, obstinately refusing to retract, when the interposition of Clement was sought. He did not evoke the case but, in terms of remarkable deference, July 1, 1531, he suggested to Manrique that, if nothing else was alleged against Ortiz, he might be held as sufficiently punished by his long imprisonment and might be restored to liberty, in view of his blameless life and the profit to souls to be expected from his preaching. This Clement asked as a favor, moved only by Christian charity and zeal for the salvation of souls.[337] To this carefully guarded request the Inquisition turned a deaf ear. If the trial of Ortiz came to an end in February, 1532, it was because he voluntarily submitted himself completely and his sentence was by no means light, including public penance, which was rarely inflicted on an ecclesiastic.[338] Paul III was more decided when his intervention was asked by Charles V, who, in spite of his bitter protests against papal interference, found himself obliged to appeal in behalf of his favorite preacher, Fray Alonso Virues. The Seville tribunal had prosecuted the