Great Britain's diplomatic dispute with America, concerning the northwestern boundary, was satisfactorily settled by the Oregon treaty, signed on June 15. Before this a peremptory demand had been put forward by the American Congress that the joint occupation of Oregon should cease. The British originally claimed all the territory west of the Rocky Mountains, from Mexico to Alaska. For years the land was settled jointly. Now the forty-ninth degree of northern latitude was accepted as the boundary between British North America and the United States. The Columbia River was retained by the United States, with free navigation conceded to English ships, while the seaport of Vancouver, the importance of which was not as yet recognized, fell to England. The value of this possession was soon revealed. Agents of the British Hudson's Bay Company selected Victoria, on the Island of Vancouver, as the most promising British port in the Pacific. During this same year, Dr. John Rae, by sledge journeys of more than 1,200 miles, explored the northernmost region, Boothia, wherein was determined the northern magnetic pole. [Sidenote: Ether in surgery] [Sidenote: Chloroform] On October 16, Dr. J.C. Warren of Boston, to whom Drs. Wells and Morton had communicated their discoveries with sulphuric ether, demonstrated the potency of the drug in a public test. A severe operation was performed at the Boston Hospital, in the presence of some of the foremost medical men of the city, while the patient remained unconscious. The news was heralded abroad and was received by medical men throughout the world as a new revelation. Dr. Oliver Wendell Holmes, the famous physician and author, named the new method "Anaesthesia." The credit of the new discovery was claimed forthwith by several persons--notably by Dr. Charles T. Jackson of Boston, and Dr. Crawford W. Long of Alabama. A few months after the value of ether in surgery had come to be clearly recognized, a Scotch surgeon, Sir J.V. Simpson, discovered that chloroform could be administered with analogous effect. [Sidenote: Mexican war begun] [Sidenote: Mexican success] [Sidenote: American reverse at Fort Brown] [Sidenote: Palo Alto] [Sidenote: Resaca de la Palma] [Sidenote: Invasion of Mexico]