_Oliver Wendell Holmes._--The many-sided activity of Dr. Holmes extended to the writing of three novels--“medicated novels” they have been called, but the term does not apply to all equally well. Certainly they all belong to the large and increasing group of “problem novels.” The first, “Elsie Venner: a Romance of Destiny” (1861), published when the author had passed the half-century mark, made its first appearance as “The Professor’s Story” in _The Atlantic Monthly_. The mother of Elsie Venner, a short time before giving birth to her child, was fatally bitten by a _crotalus_ or rattlesnake, and from birth the child is partially endowed with a serpent nature, which enables her to exercise a peculiar influence over those with whom she is brought into contact, especially the sensitive schoolmistress Helen Darley. “The real aim of the story,” says Dr. Holmes himself, “was to test the doctrine of ‘original sin’ and human responsibility for the disordered volition coming under that technical denomination. Was Elsie Venner, poisoned by the venom of a _crotalus_ before she was born, morally responsible for the ‘volitional’ aberrations which, translated into acts, become what is known as sin, and, it may be, what is punished as crime? If, on presentation of the evidence, she becomes by the verdict of the human conscience a proper object of divine pity and not of divine wrath, as a subject of moral poisoning, wherein lies the difference between her position at the bar of judgment, human or divine, and that of the unfortunate victim who received a moral poison from a remote ancestor before he drew his first breath?” It will thus be seen that what the author intended was nothing less than an onslaught upon one of the great fundamental dogmas of orthodox theology. Fifty years ago, this was a bold undertaking indeed. The intensely tragic motive of the novel is relieved by some chapters of pure comedy, in which figure the mean, calculating, money-making Silas Peckham, the vulgar splurging Sprowles, and a varied group of other minor characters. “The Guardian Angel” (1867) forms a natural sequel to “Elsie Venner”; it deals with some of the problems of heredity, attempting “to show the successive evolution of some inherited qualities in the character of Myrtle Hazard,” the heroine. Less tragic than the earlier tale, “The Guardian Angel” is more pleasant to read, and a more artistic creation. An interesting plot is skilfully worked out and the characterisation is subtle and true. In his third novel, “A Mortal Antipathy” (1885), Dr. Holmes at seventy-six plainly showed that he had passed his creative period. He yielded, to a much greater degree than in the other stories, to the rambling propensity which, charming and natural enough in “The Autocrat of the Breakfast Table,” seriously mars the continuity of a novel in which plot-interest is intended to figure. In this the author deals with the influence on a