A Manual of Clinical DiagnosisTodd, James Campbell
Science
A Manual of Clinical Diagnosis
Todd, James Campbell
Diagnosis, Laboratory
In films which are properly stained with Wright's fluid the young
organisms are small, round, ring-like or irregular, sky-blue bodies,
each with a very small, sharply defined, reddish-purple chromatin
mass. Many structures--deposits of stain, dirt, blood-plaques lying
upon red cells, etc.--may simulate them, but should not deceive one
who looks carefully for both the blue cytoplasm and the reddish-purple
chromatin. A plaque upon a red corpuscle is surrounded by a colorless
zone rather than by a distinct blue body. Young estivo-autumnal
parasites commonly take a "ring" form (the chromatin mass representing
the jewel), which is infrequently assumed by the other varieties. The
older tertian and quartan organisms show larger sky-blue bodies with
more reticular chromatin, and contain brown granules of pigment,
which, however, is less evident than in the living parasite. The
chromatin is often scattered through the cytoplasm or apparently
outside of it, and is sometimes difficult to see clearly. Typical
"segmenters" present a ring of rounded segments or spores, each with a
small, dot-like chromatin mass. With the tertian parasite, the
segments more frequently form an irregular cluster. The pigment is
collected near the center or scattered among the segments. In
estivo-autumnal fever usually only the small "ring bodies" and the
crescentic and ovoid gametes are seen in the blood. The gametes are
easily recognized. Their length is somewhat greater than the diameter
of a red corpuscle. Their chromatin is usually centrally placed, and
they contain more or less coarse pigment. The remains of the {194} red
cell often form a narrow rim around them or fill the concavity of the
crescent.
While the parasites are more easily found in stained preparations, the
varieties are more easily differentiated in fresh blood. The chief
distinguishing points are included in the following table:
VARIETIES OF THE MALARIAL ORGANISM
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