However modern, in a geological point of view, we may consider the Pleistocene epoch, it is evident that causes more general and powerful than the intervention of man have occasioned the disappearance of the ancient fauna from so many extensive regions. Not a few of the species had a wide range; the same Megatherium, for instance, extended from Patagonia and the river Plata in South America, between latitudes 31 deg. and 39 deg. south, to corresponding latitudes in North America, the same animal being also an inhabitant of the intermediate country of Brazil, where its fossil remains have been met with in caves. The extinct elephant, likewise, of Georgia (_Elephas primigenius_) has been traced in a fossil state northward from the river Alatamaha, in lat. 33 deg. 50' N. to the polar regions, and then again in the eastern hemisphere from Siberia to the south of Europe. If it be objected that, notwithstanding the adaptation of such quadrupeds to a variety of climates and geographical conditions, their great size exposed them to extermination by the first hunter tribes, we may observe that the investigations of Lund and Clausen in the ossiferous limestone caves of Brazil have demonstrated that these large mammalia were associated with a great many smaller quadrupeds, some of them as diminutive as field mice, which have all died out together, while the land shells formerly their contemporaries still continue to exist in the same countries. As we may feel assured that these minute quadrupeds could never have been extirpated by man, so we may conclude that all the species, small and great, have been annihilated one after the other, in the course of indefinite ages, by those changes of circumstances in the organic and inorganic world which are always in progress, and are capable in the course of time of greatly modifying the physical geography, climate, and all other conditions on which the continuance upon the earth of any living being must depend.[158-A]