D'Alembert attacked the analysis of Bernoulli: at first in regard to the uncertainty of his two hypotheses, then in regard to its insufficiency in this, that no comparison was made of the immediate danger, although very small, of dying of inoculation, to the very great but very remote danger of succumbing to natural smallpox. This consideration, which disappears when one considers a great number of individuals, is for this reason immaterial for governments and the advantages of inoculation for them still remain; but it is of great weight for the father of a family who must fear, in having his children inoculated, to see that one perish whom he holds most dear and to be the cause of it. Many parents were restrained by this fear, which the discovery of vaccine has happily dissipated. By one of those mysteries which nature offers to us so frequently, vaccine is a preventive of smallpox just as certain as variolar virus, and there is no danger at all; it does not expose to any malady and demands only very little care. Therefore the practice of it has spread quickly; and to render it universal it remains only to overcome the natural inertia of the people, against which it is necessary to strive continually, even when it is a question of their dearest interests. The simplest means of calculating the advantage which the extinction of a malady would produce consists in determining by observation the number of individuals of a given age who die of it each year and subtracting this number from the number of deaths at the same age. The ratio of the difference to the total number of individuals of the given age would be the probability of dying in the year at this age if the malady did not exist. Making, then, a sum of these probabilities from birth up to any given age, and subtracting this sum from unity, the remainder will be the probability of living to that age corresponding to the extinction of the malady. The series of these probabilities will be the table of mortality relative to this hypothesis, and we may conclude from it, by what precedes, the mean duration of life. It is thus that Duvilard has found that the increase of the mean duration of life, due to inoculation with vaccine, is three years at the least. An increase so considerable would produce a very great increase in the population if the latter, for other reasons, were not restrained by the relative diminution of subsistences.