In the first stage, the organs are of normal size, weight and color, the latter being however, in some cases, a little paler than usual. Their capsule is easily stripped off, and their surface is smooth. The waxy degeneration begins in the capillary tufts of the Malpighian bodies, and in the transverse fibres of the middle coat of the small arteries. On these there are thickenings here and there, presenting the same sago-like translucency as is seen in the tufts. In the second stage, the kidneys are increased in bulk and weight; the capsule is easily stripped off, and the surface smooth and pale. The cortex is thick and white, and presents much the appearance of white beeswax. Under the microscope, we see the Malpighian bodies and arteries degenerated as just described, and in addition many of the tubules full of matter, not dense and opaque as in the inflammatory form, but tolerably transparent, consisting of hyaline tube casts. Their epithelium is swollen, and their basement membrane may also be waxy. It is to this form of disease that the term “waxy kidney” is most applicable. In the third stage, that of atrophy, the organ is reduced in bulk, from about the natural size to a fourth or even less. Its weight is also diminished. The capsule may be torn off without much difficulty. The surface is rough, granular, and of a pale, waxy color. On section the cortical substance is found much diminished, while the cones are nearly natural. The Malpighian bodies are large and closely grouped together; the smaller arteries dilated and their walls thickened. A few tubules remain distended, but most are collapsed, and are represented only by fibrous tissues. 3. _The Cirrhotic or Contracting Form._ This consists of an hypertrophy of the connective tissue of the organ, and a consequent atrophy of all the other structures. It has been termed also “gouty kidney,” “intertubular or interstitial nephritis,” and “granular kidney.”