that there is a correlation of function between these (endocrine) glands and that some cases of sterility are probably due to a derangement of this correlation.” Biedl (45) concludes: “There appears to be an intimate anatomical and physiological interrelationship between the different blood glands which is manifested clinically by the fact that the pathological disturbance of one gland is accompanied by symptoms pointing to the functional derangement of one or more of the others. Knowing, as we do, the many sided interactivity which subsists between the different internal secretory organs, it is readily conceivable that isolated diseases of single organs of this group are very much rarer than, at the first glance, they would appear to be. In the present state of our knowledge, the only course of investigation which is open to us is to start with the known results of the functional derangement of any organ, and, by following these up, to seek the primary link in the pathological chain.” Most workers seem to agree that a special connection exists between the normal function of the adrenal cortex and the sexual organs. Tumors of the former are usually associated with sex abnormalities, and feeding young animals the gland substance seems to stimulate growth of the testes. Many arguments have been brought forward to show that the prostate produces an internal secretion. It is a well known fact that this organ atrophies after castration, and enlarges as the sex life dwindles. As has been previously stated, Serrlach and Pares reached the conclusion that the gland produces an internal secretion which controls the testicular functions and regulates the process of ejaculation. Also they state that if the prostate is removed, spermatozoa are no longer produced in the testes, and that the secretory activity of the accessory genital gland ceases. The secretion is, at any rate, a stimulus to the internal secretion of the testis. The thyroid bears a distinct biological relationship to the sexual glands. Removal of the gland results in imperfect development of the gonads, infantilism, and general torpor. Bell (42) believes that the association between the thyroid gland and the genitalia is as intimate as the relation of the pituitary to the genital functions. Of all the endocrines, perhaps the anterior lobe of the hypophysis is in most intimate correlation with reproduction. Castration results in hypertrophy of this organ, while removal of the anterior lobe usually leads to death. In those cases in which death does not ensue, it results in genital atrophy, stunting, and reduction of sexual activity. In young animals, spermatogenesis ceases entirely even after partial extirpation of the anterior lobe. Biedl (45) states that “in disease of the hypophysis, derangement of sexual activity occurs very early in the course of the disease, shown in women by the cessation of menstruation, and in men by impotence.”