[Footnote 7: _London Lancet_, May 5, 1883, p. 776.] A hyaloid thickening of the blood-vessels of the brain has been noted by Stephen Mackenzie[8] and Seymour Taylor[9] in some cases, and miliary aneurisms of the retina in one. [Footnote 8: Discussion on Diabetes, Path. Soc. of London, _London Lancet_, April 7, 1883, p. 593.] [Footnote 9: Ibid., _Lancet_, May 5, 1883, p. 774.] Of other organs, one of the most frequently found diseased is the pancreas, and, according to Senator, it is fair to assume that disease of the pancreas is present in about one-half of all cases of diabetes. As the result of increased experience, I am inclined to attach much more importance to pancreatic disease as a cause of diabetes than I did a few years ago. Among the changes found is a pseudo-hypertrophy, which consists chiefly in a hyperplasia of the connective tissue, fatty degeneration of the gland-cells, and atrophy of the glandular structure; cancerous disease; calculous concretions in the ducts with or without obstruction; and cystic dilatation. Facts bearing upon the relation of pancreatic disease to diabetes have been accumulating since Cowley first discovered calculi in the pancreas of a diabetic, and Bright pancreatic cancer in a similar case. Since then {201} instances have multiplied to such extent that it would be unprofitable to enumerate them. But in 1877, Lancereaux[10] communicated to the French Academy of Medicine specimens of profound lesion of the pancreas from cases dying of diabetes mellitus. This, he alleged, constitutes a special and distinctive variety of diabetes, characterized by sudden onset, emaciation, polydipsia, polyphagia, and peculiar alvine dejections. More recently, Depierre[11] has confirmed these observations, apparently establishing this variety of diabetes mellitus, of which a very rapid course--six months to three years--and the habitual presence of diarrhoea are characteristic; while the presence of greasy or creamy stools, and the appearance in them of undigested nitrogenous substances, may aid in the diagnosis. Precisely such a case, running the same rapid course--less than one year--with emaciation, uncontrollable diarrhoea, creamy stools, jaundice, and pancreatic disease, came under the writer's care in 1882. At the autopsy the pancreas was found enlarged, and numerous gritty particles were disseminated through it. [Footnote 10: "Notes et réflexions à propos de deux cas de diabète sucre avec altération du pancréas," _Bull. Acad. de Méd._, Paris, 1877, 2d Serie, vi. 1215-1240.] [Footnote 11: _Med. News and Abstract_, vol. xxxix., June, 1881, p. 344, from _Jour. de Méd. et de Chir. pratiques_, Dec, 1880.]