25th. Pain of head gone; mind indistinct; tongue dry: stools passed in bed; pulse 105. Pains in the joints; swelling and redness of left fore-arm. 27th. Mind more and more indistinct; pressure on any part of the body produces extreme pain; joints the same; died next day. At this period attention had not been awakened to the peculiar disease of the joints hereafter to be described; they were not therefore examined; but without doubt the affection was of the same nature. _Head._ Dura mater vascular, and adhered with preternatural firmness to the skull; pia mater vascular; substance of brain natural; pituitary gland suppurating; the lateral and the third ventricles full of serous fluid; one ounce at base. _Thorax._ [Lungs emphysematous; several points of tubercular suppuration in left.] _Abdomen._ Mucous membrane of small intestines inflamed without ulceration. CASE XXXIV. JAMES DENNIE, æt. 28, labourer. Admitted on the 8th day of fever, which attacked with usual symptoms: at present pain of head; little sleep; eyes dull and heavy; some cough; respiration hurried; abdomen not tender; tongue white; pulse 112, weak; prostration. 9th. Pain of head increased; delirium; eyes suffused; cough and hurried respiration continue. 10th. Pain of head gone; constant and violent delirium; no sleep; pulse 108. 11th. Delirium gone; profound coma; muscular tremor; respiration hurried; pulse 108. 12th. Coma deeper; extreme restlessness; respiration more hurried; stools and urine passed in bed. Died. _Head._ Arachnoid vascular; substance both of cerebrum and cerebellum vascular; all the ventricles full of serum; viscera of thorax and abdomen healthy. CASE XXXV. CHARLOTTE WATTS, æt. 9. Previous history of disease unknown: at present scarcely at all sensible; almost constant crying; frequent rolling of the head on the pillow; countenance anxious; pulse not to be counted from her extreme restlessness; respiration hurried; abdomen not tender; lips and teeth sordid. 2d day after admission constant noisy delirium; pulse 120. 17th. Almost imperceptible, but still gradual improvement since last report; more sensible; no delirium; but mind throughout extremely peevish and fretful; stools have constantly been and still are passed in bed; pulse 116. 19th. Large sloughing sores on loins and hips; erysipelas of surrounding integuments; pulse 112, weak. 27th. Sloughs have extended between the shoulders, along the back, and over both hips; great emaciation; extreme prostration; mind continues very fretful; pulse 110, very weak. 37th. Gradually grew weaker and weaker until this day, when she died.