8th. Eruption changed to copper-colour; tongue dry; pulse 112. 10th. Inflammation of parotid gland. 18th. Tumour of left parotid exceedingly hard and slowly suppurating; slight difficulty in swallowing; pulse 96. 21st. Tumour opened last night and discharged two ounces of bloody pus; pulse 108. 28th. Alternately mended a little and then fell back to his former state until last night, when swelling of right wrist and left knee came on, attended with excruciating pain and great heat without any discoloration: 12 leeches have been applied with considerable relief: mind confused; no sleep; countenance anxious; face flushed; rigors; pulse 135. 24th. Other wrist and knee have begun to swell and are excessively painful; left wrist and knee which had been more easy, again extremely painful; vomiting; respiration hurried; pulse 116, weak. Died. _Head._ Much serum both in ventricles and at base. _Thorax._ Viscera healthy. _Abdomen._ Mucous membrane of the ilium ulcerated and extremely dark. All the large joints swollen and red: on opening the knee joints they were found to contain several ounces of serum mixed with pus; the cellular tissue in the neighbourhood was partly inflamed, and partly mortified and sloughing: both wrists were in a similar condition. CASE XII. JAMES SOLDEN, æt. 44, plasterer. For symptoms see page 155. _Head._ Membranes of brain vascular; substance highly vascular; some effusion beneath the arachnoid. _Thorax._ Viscera healthy. _Abdomen._ Mucous membrane of ilium vascular; no ulceration; mesenteric glands enlarged. CASE XIII. JOHN CLARK, æt. 17. For symptoms see page 156. _Head._ Corresponding portions of the pericranium and dura mater detached from the occipital bone to the extent of four inches in length by three in width; coagulated blood effused between the dura mater and the cranium; vessels of the membranes turgid with blood; substance of brain vascular; effusion between the membranes; a little at base. _Thorax._ Viscera healthy. _Abdomen._ Mucous membrane of ilium greatly inflamed; cæcum ulcerated.