CASE LXXX. ELIZABETH HAMMOND, æt. 50, married. Admitted on the 28th day of fever, which came on with the ordinary symptoms; at present she is without pain in any organ; face peculiarly pallid; some cough; pulse 120, and weak. 29th. No tenderness of abdomen; no pain; cough; delirium; pulse 110. 32d. Cough; delirium; pain, redness, swelling, and vesication of left leg; pulse 120, weak. 35th. Tongue scarcely to be protruded; very tremulous; three stools; cough; much delirium; pulse 120, very weak; the vena saphena major easily to be traced along its whole course, being hard, tense, and painful. 40th. Delirium; muscular tremor; much convulsive twitching of the face; pulse 130, extremely weak. 40th. Delirium continues; muscular tremor increased; great prostration; leg more swollen, the tumefaction now extending up the thigh; the saphena traced to the middle of the thigh where it ends in a varix, which has for the last two days greatly enlarged; lymphatics along the course of the vein swollen; integuments of a dusky red colour; much thickening and hardening of the cellular tissue over the femoral vessels; says she has no pain in the leg; mind dull and confused, yet answers coherently when spoken to. 43d. Delirium continues; prostration increases; lips and teeth covered with dark-coloured sordes; affected leg darker in colour, and colder to the touch; pulse 120; no tenderness of the abdomen, nor has it been tender through the whole course of the disease. 44th. Died. _Abdomen._ Mucous membrane of ilium, cæcum, and commencement of colon extensively ulcerated; viscera of head and thorax healthy; slight swelling of the whole left extremity; ankle œdematous; the cellular tissue along the entire course of the saphena major and femoral vein exceedingly condensed and hard; on opening the saphena vein there was found a layer of coagulable lymph lining its whole internal surface, which was universally vascular and rough; in many places, especially about the knee, the coats of the vein were very much thickened, so that the calibre of the vessel was diminished at least one-half its size; the lower part of the femoral vein was in a similar state, but its superior portion and the external iliac were little, if at all affected. CASE LXXXI. MARY FORD, æt. 30, married. Admitted on the 8th day of fever, which in addition to the ordinary symptoms, was attended at the commencement with pain in the abdomen, which continued for some time, but which is now entirely gone: states that the bowels have been very loose for upwards of a month past; tongue loaded and red; thirst; no uneasiness of chest; some cough; pain of head, which was severe in the commencement, quite gone; pulse 90; great prostration. 9th. No pain in any organ; tongue unchanged; two stools, light and offensive; delirium. 10th. Four stools in bed; delirium; lies on back quite prostrate; pulse 105, weak.